Programs

This episode was recorded on March 8th, 2026 at the Culture Center Theater in Charleston, WV. The lineup includes Cyril Neville, Deke Dickerson & Los Straitjackets, Sons of Town Hall, Amanda Pascali. https://bit.ly/3OyzFLX

For most of human history, people went about their daily lives with a worm or two (or fifty) in their guts. Only in the past century, with pharmaceuticals and sanitation practices, have we made significant strides towards deworming the whole of humanity. And that’s typically been thought of as a good thing, because having too many worms in your body can–quite literally–suck the life out of you. But is it possible to have… too few worms? Science wonders if deworming ourselves has actually led to an increase in certain chronic diseases. On this episode, we dive into Necator americanus, a.k.a. the American Hookworm, and its mysterious relationship with each of us. We trace the hookworm’s 118-year journey from a demonized economic depressant, to its use as a desperate D.I.Y. immunosuppressant, to its potential as a medical treatment for a number of chronic diseases, everything from asthma to MS. We’re bringing back two stories  from our 2009 episode Parasites plus new research on hookworms and autoimmune diseases, reported by Molly Webster Special thanks to Ethan Hein for the use of his remix of Mozart's Piano Concerto No. 21. Plus, Doris Pierce, and Dan and Alice Hadley. EPISODE CREDITS:  Reported by – Pat Walters and Molly Webster with help from – {{wREPORTERS}} Produced by – Matt Kielty with help from – Rebecca Rand Fact-checking by – Diane A. Kelly and Edited by  – Arianne Wack EPISODE CITATIONS: Articles –  Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes (https://pubmed.ncbi.nlm.nih.gov/37495576/) by Giacomin PR et al. Nat Commun. 2023 Jul 26 Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org. Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this bonus Desert Island Jukebox, Jim pays tribute to legendary American songwriter Chip Taylor, whose pop and country songs were recorded by countless artists— including one of Jim’s favorites, The Troggs. Taylor died on March 23, 2026, at the age of 86.Join our Facebook Group: https://bit.ly/3sivr9TBecome a member on Patreon: https://bit.ly/3slWZvcSign up for our newsletter: https://bit.ly/3eEvRnGMake a donation via PayPal: https://bit.ly/3dmt9lUSend us a Voice Memo: Desktop: bit.ly/2RyD5Ah  Mobile: sayhi.chat/soundopsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Moon lines up with the twins of Gemini this evening – the stars Pollux and Castor. Pollux is the brighter twin, and is closer to the Moon. The brilliant planet Jupiter is to the lower right of the Moon. Gemini has been around for thousands of years. Its roots trace back to ancient Babylon, as do those of many other constellations. All of them were recorded in one of the most important works of astronomy in the ancient world. Known as the Almagest, it was written by Claudius Ptolemy around the year 150. Ptolemy studied many fields, including astronomy, astrology, geology, and music theory. The Almagest is perhaps his most famous work. In it, he recorded the positions of a thousand stars, and included details on the motions of the Sun, Moon, and planets. He also discussed everything from eclipses to the length of the year. The book listed 48 constellations that were visible from northern skies – Gemini among them. The constellations weren’t given any borders – just the regions of the sky in which they appeared. And some barren regions weren’t part of any constellation. Over the centuries, astronomers shifted things around some. And they created constellations for southern skies as well. Finally, in 1930, they created an “official” list of 88 constellations. Each one was given precise borders. That gave every star a home – its own “address” in the universe. Script by Damond Benningfield

We're joined for a special Uruguay episode co-hosted by Juan Campodonico, the artist and producer at the forefront of fusing electronic and rock music with traditional Uruguayan genres like tango and murga. Featured artists include Bajofondo, El Cuarteto de Nos, Campo and Peyote Asesino. 

One family faces the Trump administration’s ban on trans people serving in the military, and responds with a surprising secret weapon. Visit thisamericanlife.org/lifepartners to sign up for our premium subscription.Prologue: Geirid and Chrissy are extreme planners. But about a year ago, they were confronted with a situation that even they had no idea how to plan for. (4 minutes)Act One: Geirid and Chrissy make an “in case of emergency, break glass” spreadsheet and get some big news. (14 minutes)Act Two: Geirid and Chrissy have less than a month to make a life-changing decision. The government gives them two options, and they try to find a third. (21 minutes)Act Three: A short story from Rachel Khong: Two people have a very consequential choice to make, given to them by God. (15 minutes)Transcripts are available at thisamericanlife.orgThis American Life privacy policy.Learn more about sponsor message choices.