Programs

Five Faves: 2005 Edition Executive producer Adam Harris walks us through some of the most memorable sets and performances from his first season with Mountain Stage, twenty short years ago. Tune in to hear The Del McCoury Band, Alison Krauss & Union Station, Lizz Wright, Guy Clark, Nanci Griffith, Odetta and more! https://bit.ly/4sptuc8

When neuroscientist Madeline Lancaster was a brand new postdoc, she accidentally used an expired protein gel in a lab experiment and noticed something weird. The stem cells she was trying to grow in a dish were self-assembling. The result? Madeline was the first person ever to grow what she called a “cerebral organoid,” a tiny, 3D version of a human brain the size of a peppercorn.In about a decade, these mini human brain balls were everywhere. They were revealing bombshell secrets about how our brains develop in the womb, helping treat advanced cancer patients, being implanted into animals, even playing the video game Pong. But what are they? Are these brain balls capable of sensing, feeling, learning, being? Are they tiny, trapped humans? And if they were, how would we know?Special thanks to Lynn Levy, Jason Yamada-Hanff, David Fajgenbaum, Andrew Verstein, Anne Hamilton, Christopher Mason, Madeline Mason-Mariarty, the team at the Boston Museum of Science, and Howard Fine, Stefano Cirigliano, and the team at Weill-Cornell. EPISODE CREDITS: Reported by – Latif Nasserwith help from – Mona MadgavkarProduced by – Annie McEwen, Mona Madgavkar, and Pat Walterswith mixing help from – Jeremy BloomFact-checking by – Natalie Middleton and Rebecca Randand Edited by  – Alex Neason and Pat WaltersEPISODE CITATIONS:Videos – “Growing Mini Brains to Discover What Makes Us Human,” Madeline Lancaster’s TEDxCERN Talk, Nov 2015 (https://zpr.io/6WP7xfA27auR)Brain cells playing Pong (https://zpr.io/pqgSqguJeAPK)Reuters report on CL1 computer launch in March 2025 (https://zpr.io/cdMf8Yjvayyd) Articles – Madeline Lancaster: The accidental organoid – mini-brains as models for human brain development (https://zpr.io/nnwFwUwnm2p6), MRC Laboratory of Molecular Biology What We Can Learn From Brain Organoids (https://zpr.io/frUfsg4pxKsb), by Carl Zimmer. NYT, November 6, 2025Ethical Issues Related to Brain Organoid Research (https://zpr.io/qyiATHEhdnSa), by Insoo Hyun et al, Brain Research, 2020 Brain organoids get cancer, too, opening a new frontier in personalized medicine (https://zpr.io/nqMCQ) STAT Profile of Howard Fine and his lab’s glioblastoma research at Weill Cornell Medical Center: By re-creating neural pathway in dish, Stanford Medicine research may speed pain treatment (https://zpr.io/UnegZeQZfqn2) Stanford Medicine profile of Sergiu Pasca’s research on pain in organoids A brief history of organoids (https://zpr.io/waSbUCSrL9va) by Corrò et al, American Journal of Physiology – Cell Physiology, Books – Carl Zimmer Life’s Edge: The Search for What it Means to be Alive (https://carlzimmer.com/books/lifes-edge/)Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)!Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Hosts Jim DeRogatis and Greg Kot close the book on 2025 by doing a final round of obituaries, playing favorite singles and sharing a mixtape that documents the ups and downs of the year that was. Greg's MixtapeJoin our Facebook Group: https://bit.ly/3sivr9TBecome a member on Patreon: https://bit.ly/3slWZvcSign up for our newsletter: https://bit.ly/3eEvRnGMake a donation via PayPal: https://bit.ly/3dmt9lUSend us a Voice Memo: Desktop: bit.ly/2RyD5Ah  Mobile: sayhi.chat/soundops Featured Songs:SPRINTS, "Something's Gonna Happen," All That Is Over, City Slang and Sub Pop, 2025The Beatles, "With A Little Help From My Friends," Sgt. Pepper's Lonely Hearts Club Band, Parlophone, 1967The Redwalls, "It's Alright," Universal Blues, Undertow, 2003Joe Ely, "Boxcars," Honkey Tonk Masquerade, MCA, 1978The Mavericks, "There Goes My Heart," What a Crying Shame, MCA Nashville, 1994The Band, "Chest Fever," Music from Big Pink, Capitol, 1968Chappell Roan, "The Subway," (Single), Amusement, 2025Annabelle Dinda, "The Hand," (Single), Self-Released, 2025Huntrix, "Golden," KPop Demon Hunters, Republic, 2025Hayley Williams, "True Believer (Live on Tonight Show)," Ego Death at a Bachelorette Party, Post Atlantic, 2025Bad Bunny, "BAILE INoLVIDABLE," DeBÍ TiRAR MáS FOToS, Rimas, 2025MSPAINT, "Angel," No Separation, Convulse, 2025Cardi B, "Outside," Am I the Drama?, Atlantic, 2025Taylor Swift, "The Fate Of Ophelia," The Life of a Showgirl, Republic, 2025Sharon Van Etten, "Somethin' Ain't Right," Sharon Van Etten and The Attachement Theory, Jagjaguwar, 2025The Penrose Web, "I Dreamt I Woke Up Dead," It's…The Penrose Web, Fools Paradise and Gare Du Nord, 2025Peter Peter Hughes, "The End of Your Empire," Half-Staff Blues, Tired Media, 2025Mavis Staples, "Chicago," Sad and Beautiful World, Anti, 2025The Belair Lip Bombs, "Again and Again," Again, Third Man, 2025The Bug Club, "How to Be a Confidante," Very Human Features, Sub Pop, 2025Perfume Genius, "It's a Mirror," Glory, Matador, 2025Ed Kuepper and Jim White, "The 16 Days," After The Flood, Remote Control, 2025Mekons, "You're Not Singing Anymore," Horror, Fire, 2025Spinal Tap, "Tonight I'm Gonna Rock You Tonight," This Is Spinal Tap, Polydor, 1984See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Earth passed by Jupiter yesterday. Now, we’re beginning to leave the giant planet behind. We’ll loop past it again early next year. That passage is known as opposition – Jupiter lines up opposite the Sun in our sky. It’s closest to us then, so it shines brightest for the year. And it’s in view all night. Jupiter is much farther from the Sun than Earth is, so it takes about 12 years to complete a single orbit. Earth follows a much shorter path around the Sun, and it moves faster. So it passes Jupiter every 13 months. As we approach Jupiter, the planet stops its normal eastward motion against the background of stars. For a while, it moves backward – a period known as retrograde. Jupiter itself doesn’t change direction. Instead, the shift is a result of our changing viewing angle. It’s like passing a car on the highway. For a little bit, the other car looks like it’s moving in reverse compared to the background of buildings and trees. As the gap opens, though, it appears to resume its forward motion. Jupiter will reach that point on March 11th – shifting gears as it circles the Sun. Jupiter looks like a brilliant star – brighter than any other planet or star in the night sky now. The twin stars of Gemini are close by. Pollux, the brighter twin, is close to the left of Jupiter at nightfall. Castor is farther to the upper left. The whole group soars high across the south during the night. Script by Damond Benningfield

It's a special THE MAVERICKS takeover episode! The critically acclaimed roots rock / country band The Mavericks talk to us about the album 'En Español,' a Spanish language album that highlights the Latin music roots and influences shared by members Raul Malo and Eddie Perez.

People discovering information about their own lives that they did not know, and suddenly everything looks very different. Visit thisamericanlife.org/lifepartners to sign up for our premium subscription.Prologue: When Pete turned 18, his dad took him on a drive to reveal a family secret he was finally old enough to know. (11 minutes)Act One: Sometimes, a lore drop comes when you least expect it.  That happened to Jake Cornell and his grandmother. Producer Aviva DeKornfeld talked to Jake about it. (14 minutes)Act Two: Ben Austen had a kind of new lore drop happen to him recently. But it was not the clarifying kind of lore drop, where everything suddenly makes sense — it was kind of the opposite. (29 minutes)Transcripts are available at thisamericanlife.orgThis American Life privacy policy.Learn more about sponsor message choices.