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This episode was recorded on May 17th, 2026 at the Culture Center Theater in Charleston, WV. The lineup includes Paul Thorn, Ray Benson, Sunny Sweeney, Andy Friedman. https://bit.ly/4afWiMG⁠

After reading something that said her menstrual cycle changes her brain each month, Senior Correspondent Molly Webster goes on a reporting mission to see if that’s true, and, if so, how. This journey into sex hormones and the brain involves females and males, and exacting self-experimentation. It gets into PTSD, and ends with a new twist on self-care (hint: it’s biological). And, it starts to reveal a sneaky truth: that each one of us is at the mercy of a crashing sea of chemicals inside of us – those things we call hormones. Special thanks to Emily Jacobs, Laura Pritschet, Pavel Shapturenka, and Dr. Catherine Woolley.EPISODE CREDITS: Hosted by – Molly Webster Reported by – Molly Webster Produced by – Mona Madgavkar with help from – Molly Webster Fact-checking by – Diane A. Kelly EPISODE CITATIONS: Articles –  **The experiments we feature in this episode are called: 28andMe, 28andOC, and 28andHe, all of which took place at Emily Jacobs lab at the University of California, Santa Barbara.**  The 28 Project (https://zpr.io/CSx6MnwZjRvp), background from the Jacobs lab For more on how much variability there is between female and male animals, check out this “groundbreaking” study, referenced by Emily Jacobs in our episode Sex Bias in Neuroscience and Biomedical Research(https://zpr.io/ZRgKZzdNejUA),  by Beery AK, Zucker I., Neurosci Biobehav Rev. 2011 Dr. Catherine Woolley has revolutionized the field of neuroscience and sex hormones, here’s more about her work … Sex Differences in the Brain Get Down to the Molecular Level Sex (https://zpr.io/UNCLE9J782N5), by Stephanie DeMarco, PhD, The Scientist.com Hormonal Effects on the Brain (https://zpr.io/DvNM9EkXdtGG), by Woolley, C.S. and Schwartzkroin, P.A. Epilepsia Data sets – 28andMe and 28andOC (https://zpr.io/hbXVNTVp2Q7j): 28andHe (https://zpr.io/sZXhfMbMwKb7) Audio –  In the episode, we mention Dr. Russ Poldrack and the Midnight Scan Club, as inspo for self-experimentation The Midnight Scan Club (https://zpr.io/CLBhNQSxK844), by Science Friday.   Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org. Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this bonus DIJ, Greg pays tribute to jazz giant Sonny Rollins. Rollins died on May 25, 2026, at the age of 95.Join our Facebook Group: https://bit.ly/3sivr9TBecome a member on Patreon: https://bit.ly/3slWZvcSign up for our newsletter: https://www.patreon.com/collection/2136865Make a donation via PayPal: https://bit.ly/3dmt9lUSend us a Voice Memo: Desktop: bit.ly/2RyD5Ah  Mobile: sayhi.chat/soundopsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A star system on the far side of the galaxy keeps blowing up. Since 1863, astronomers have recorded 12 outbursts from the system – the most recent just four years ago. The flare-ups are powered by a complicated interplay between a dead star and a companion that may be dying. U Scorpii probably is more than 60,000 light-years away, far on the other side of the heart of the Milky Way Galaxy. Most of the time, the system is quite faint. But during the outbursts, it can flare 10,000 times brighter in just a few hours. It starts to fade quickly, but it takes about two months to return to its “quiet” state. The system consists of two stars in a tight orbit. One of them is a white dwarf – the dead core of a Sun-like star. The other star is headed toward the same fate. It’s at the end of the prime phase of life, so it’s starting to puff up. The white dwarf “steals” some of the gas from its surface, forming a swirling disk. Some of the gas piles up on the white dwarf. Eventually, the gas gets so hot, it sets off a nuclear blast, making the system flare up. The outburst blows away all or part of the disk. Before long, though, the process starts all over again – leading to another explosion a few years later. U Scorpii is in Scorpius, which is low in the south-southeast at nightfall. The system is above the curving line of stars that outlines the scorpion’s body and tail. Script by Damond Benningfield

This week is an exploration of Blues music, Latino style.  Featured artists include Santana, Los Lonely Boys, Diamante Electrico, Bunbury, Andres Calamaro and many more.

We spend an hour in the last two minutes of the fourth quarter, behind and desperate, with people trying any damn thing they can think of. Visit thisamericanlife.org/lifepartners to sign up for our premium subscription.Prologue: Five years after Ora first started experiencing mysterious and debilitating health problems, she decides to try a treatment that she knows very well might kill her. Host Ira Glass talks to her about the experience. (9 minutes)Act One: Two lawyers have just three months to stop their client's execution. In Texas, where this story takes place, these kinds of appeals to get people off death row fail 94% of the time. (38 minutes)Act Two: At the Otay Mesa Detention Center in San Diego, migrants figured out an ingenious way to communicate with the activists gathered outside of the detention center’s walls. (13 minutes)Transcripts are available at thisamericanlife.orgThis American Life privacy policy.Learn more about sponsor message choices.